Can Vitamin D Supplementation in Infancy Prevent Type 1 Diabetes?
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چکیده
second-degree relatives of patients with celiac disease, patients with type 1 diabetes, patients with immune thyroid or liver disorders, patients with Sjogrens syndrome, patients with Down or Turner syndrome, and patients with selective IgA de ciency.The key to these questions rests in further understanding the pathophysiology of celiac disease. Studies to date have included the “tip of the iceberg,” but further research is needed to identify those patients under the waterline and how to appropriately treat them.
منابع مشابه
Can vitamin D supplementation in infancy prevent type 1 diabetes?
Several recent European studies suggested that supplementing infants with vitamin D during their first year might prevent type 1 diabetes. A dose of 50 microg/day was associated with decreased diabetes risk in Finland, but the effectiveness of lower doses was not examined. The recommended dietary intake of vitamin D for U.S. infants is 5 microg/day and the tolerable upper level is 25 microg/day...
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Vitamin D directly (due to receptor activation by vitamin D) or indirectly (through regulation of calcium homeostasis) effects on the pathogenic mechanisms associated with both types of diabetes, such as pancreatic beta-cell dysfunction, impaired insulin action and systemic inflammation. It has been shown that using Vitamin D supplementation during pregnancy and infancy has relation with a redu...
متن کاملIntake of vitamin D and risk of type 1 diabetes: a birth-cohort study.
BACKGROUND Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy could affect development of type 1 diabetes. METHODS A birth-cohort study was done, in which all pregnant women (n=12055) in Oulu and Lapland, northern Finland, who were due to give birth in 1966 ...
متن کاملA double blind randomized clinical trial to investigate the effect of vitamin D supplementation on metabolic and hepato-renal markers in type 2 diabetes and obesity
Background: According to the recent studies, vitamin D deficiency has been correlated with progress in type 2 Diabetes and Metabolic Syndrome. The aim of this study was to assess the effect of vitamin D supplementation on glucose and lipid profiles, blood pressure, and biomarkers of liver and kidney in type 2 diabetic patients. Methods: In this Double blinded randomized clinical t...
متن کاملVitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis.
OBJECTIVES To assess whether vitamin D supplementation in infancy reduces the risk of type 1 diabetes in later life. METHODS This was a systematic review and meta-analysis using Medline, Embase, Cinahl, Cochrane Central Register of Controlled Trials and reference lists of retrieved articles. The main outcome measure was development of type 1 diabetes. Controlled trials and observational studi...
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